Causes

The virus of dengue fever belongs to the family flaviviridae. It is the RNA virus. Other member of the Flaviridae virus is the virus of yellow fever, virus of West Nile, virus of encephalitis of St. Louis, virus of Japanese encephalitis, virus of encephalitis of...

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Effects

The children who are below the age of 10 years get affected on the functioning of circulatory system during the dengue fever. The mortality rate lies in between the 6 to 30% and it is found that most of the death occurred in the patients of dengue...

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Treatment

It is found that at present there is no specific vaccine is found which can kill the virus of dengue fever not even a single anti virus tablets.
Dengue fever is treated by a medicine which is known as Paracetamol, an anti pyretics...

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Causes of Dengue

Virology

The virus of dengue fever belongs to the family flaviviridae. It is the RNA virus. Other member of the Flaviridae virus is the virus of yellow fever, virus of West Nile, virus of encephalitis of St. Louis, virus of Japanese encephalitis, virus of encephalitis of Tick-bone, virus of disease Kyasanur forest and last but not least the virus of fever omsk hemorrhagic. It is found that most of the disease is transmitted by ticks or mosquitoes, commonly known as anthropods and also referred by the name of arboviruses, is the virus of anthropod-borne.

The genome of the dengue virus lies between the range of 11000 bases of nucleotide which become the code for the other three types of different molecules of protein (E, C, prM) which help in making the particles of virus and even help in the formation of seven other types of molecules of protein (NS5, NS4a, NS2b, NS1, NS2a, NS3, NS4b) that are mostly found in the cells of infected host and which are needed for virus to get replicated.

Transmission

It is known that dengue fever is caused by the bite of female Aedes mosquito commonly known as A. aegypti. It is found that these types of mosquitoes live in the area of 35 degree from south and 35 degree north from the latitude which is below in the angle of elevation 1000 metres (3,300 ft). Aedes mosquitoes mainly attack during the morning time and evening time. Aedes is the mosquitoes that have its many species transmitting disease are A.scutellaris, A.albopictus and last but not least is A.polynesiensis. Humans are known for the host of virus but it is found that virus also circulates in the primates of non human. The infection from Aedes can be transmitted on a single bite. It is stated that female Aedes also get infected while sucking the blood of a person who is infected with dengue fever. Dengue is the fever which is also transmitted through the blood products which is infected and also through the donation of an organ.

The risk of dengue fever in the countries like Singapore lies between the range of 1.6 and the transfusion of dengue is 6 per 10000. During the time of pregnancy, there has been transmission from mother to the born child. It is found that there is also transmission of the virus directly from person to person.

Predisposition

Babies and the children who are in young stage are more prone to the diseases of various types. Children are very well nourished in contrast to various infections. Other factors which are very risky are from sex of female and the index of weighted body. Each serotype is responsible for the disease to get spectrum which in turn become the risky factor of virus strain. There are four types of serotypes as we already know and it is also known that the one serotype can only give lifelong immune capacity to the type which is similar to it but cannot give good immune capacity to other serotypes.

Polymorphism is known for creating the link with increase in complications of dengue virus. There are certain examples which contain the code for the various genes of proteins. They are DC-sign, TGFβ, TNFa, PLCe1 and lectin of mannan-binding and there is some other forms leukocyte antigen of human from the variations of the genes of HLA-B.